TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus

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Item Type:	Review
Title:	TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus
Creators Name:	Lautscham, G., Rickinson, A. and Blake, N.
Abstract:	For recognition by CD8+ lymphocytes, peptides derived from cytosolically processed antigen need to access MHC class I molecules en route to the target cell surface. This normally requires peptide transport into the endoplasmic reticulum via the transporter associated with antigen presentation (TAP) complex. However, as recent work with Epstein-Barr virus illustrates, TAP-independent presentation pathways also exist and are growing in number.
Keywords:	Epstein-Barr Virus (EBV), Hydrophobicity, MHC Class I Processing, TAP Independence
Source:	Microbes and Infection
ISSN:	1286-4579
Publisher:	Elsevier
Volume:	5
Number:	4
Page Range:	291-299
Date:	April 2003
Official Publication:	https://doi.org/10.1016/S1286-4579(03)00031-5
PubMed:	View item in PubMed

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