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| Item Type: | Article |
|---|---|
| Title: | Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells |
| Creators Name: | Schueler, T. and Blankenstein, T. |
| Abstract: | CD8+ effector T cells recognize malignant cells by monitoring their surface for the presence of tumor-derived peptides bound to MHC class I molecules. In addition, tumor-derived Ags can be cross-presented to CD8+ effector T cells by APCs. IFN-γ production by CD8+ T cells is often critical for tumor rejection. However, it remained unclear whether 1) CD8+ T cells secrete IFN-γ in response to Ag recognition on tumor cells or APCs and 2) whether IFN-γ mediates its antitumor effect by acting on host or tumor cells. We show in this study that CD8+ effector T cells can reject tumors in bone marrow-chimeric mice incapable of cross-presenting Ag by bone marrow-derived APCs and that tumor rejection required host cells to express IFN-γR. Together, CD8+ effector T cells recognize Ag directly on tumor cells, and this recognition is sufficient to reject tumors by IFN-γ acting on host cells. |
| Keywords: | Antigen Presentation, Antigen-Presenting Cells, Bone Marrow Cells, CD8-Positive T-Lymphocytes, Cultured Cells, Cultured Tumor Cells, Experimental Melanoma, Graft Rejection, Inbred C57BL Mice, Interferon Type II, Interferon Receptors, Knockout Mice, Neoplasm Antigens, Neoplasm Transplantation, Ovalbumin, Transgenic Mice, Animals, Mice |
| Source: | Journal of Immunology |
| ISSN: | 0022-1767 |
| Publisher: | American Association of Immunologists |
| Volume: | 170 |
| Number: | 9 |
| Page Range: | 4427-4431 |
| Date: | 1 May 2003 |
| Official Publication: | http://www.jimmunol.org/cgi/content/abstract/170/9/4427 |
| PubMed: | View item in PubMed |
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