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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

Item Type:Article
Title:Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence
Creators Name:Franke, P., Wendel, B., Knapp, M., Schwab, S.G., Neef, D., Maier, W., Wildenauer, D.B. and Hoehe, M.R.
Abstract:Objective. - In a modified case-control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human μ-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods. - In contrast to classical case-control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany. Results. - For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. Conclusions. - Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case-control association studies of opioid dependent individuals.
Keywords:Addiction, Case-Control Study, Opioids, OPRM1, Polymorphism
Source:European Psychiatry
ISSN:0924-9338
Publisher:Editions Scientifiques Medicales Elsevier
Volume:18
Number:1
Page Range:18-22
Date:1 February 2003
Official Publication:https://doi.org/10.1016/S0924-9338(02)00005-6
PubMed:View item in PubMed

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