Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Translational control of SCL-isoform expression in hematopoietic lineage choice

[thumbnail of 6645oa.pdf] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
293kB

Item Type:Article
Title:Translational control of SCL-isoform expression in hematopoietic lineage choice
Creators Name:Calkhoven, C.F., Mueller, C., Martin, R., Krosl, G., Hoang, T. and Leutz, A.
Abstract:We investigated the translational regulation of SCL protein expression and its role in hematopoietic lineage choice. We show that the expression of different SCL protein isoforms is regulated by signal transduction pathways that modulate translation initiation factor (eIF) function. A conserved small upstream open reading frame (uORF) in SCL transcripts acts as a cis-regulatory element for isoform expression. At the onset of erythroid differentiation, truncated SCL protein isoforms arise by alternative translation initiation and favor the erythroid lineage. In comparison, full-length SCL proteins are more efficient at enhancing the megakaryocyte lineage. Together, our studies unravel translational control as a novel mechanism regulating hematopoietic outcome.
Keywords:EIF2{alpha}, EIF4E, Hematopoiesis, Lineage commitment, Translation Initiation, UORF, Animals, Cricetinae
Source:Genes & Development
ISSN:0890-9369
Publisher:Cold Spring Harbor Laboratory Press
Volume:17
Number:8
Page Range:959-964
Date:15 April 2003
Official Publication:https://doi.org/10.1101/gad.251903
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library