Prognoserelevanz von biologischen und molekularen Markern in der Onkologie : Kriterien fur Studienplanung und -Interpretation. [Prognostic relevance of biological and molecular markers in oncology. Criteria for planning and interpreting studies]

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Item Type:	Article
Title:	Prognoserelevanz von biologischen und molekularen Markern in der Onkologie : Kriterien fur Studienplanung und -Interpretation. [Prognostic relevance of biological and molecular markers in oncology. Criteria for planning and interpreting studies]
Creators Name:	Bollschweiler, E., Schneider, P.M., Moenig, S.P., Altendorf-Hofmann, A., Mansmann, U., Lehmacher, W., Schlag, P.M., Merkel, S., Hohenberger, W., Izbicki, J.R., Hermanek, P. and Hoelscher, A.H.
Abstract:	Experts on different specialities (surgery, pathology, molecular biology and medical statistics) discussed the evaluation of prognostic factors during a workshop. The most important results presented are: (1) the prognostic relevance of new biological or molecular markers must be evaluated in a phase-III prognostic study. To establish such a marker in the UICC-TNM-classification in at least two different centers, two multivariate analyses according to defined criteria are necessary; (2) the standards of laboratory methods have to be defined, e.g.,which method to apply for RNA-analysis, which materials to used, etc; (3) intensive data analysis should be done before using methods of multivariate analysis. The criteria for the presentation of survival curves are given in detail; (4) in multivariate analysis, the Cox proportional hazard regression for survival outcomes is discussed with explanations and examples of the terms relative risk, odds-ratio, hazard and relative hazard. The arrangement and interpretation of a good prognostic study should be performed as an interdisciplinary approach.
Keywords:	Prognosis, Biological Marker, Molecular Marker, TNM-Classification, Univariate Analysis, Multivariate Analysis
Source:	Chirurg
ISSN:	0009-4722
Publisher:	Springer
Volume:	74
Number:	2
Page Range:	139-144
Date:	February 2003
Official Publication:	https://doi.org/10.1007/s00104-002-0557-7
PubMed:	View item in PubMed

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