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| Item Type: | Article |
|---|---|
| Title: | ICOS+Th cells produce distinct cytokines in different mucosal immune responses |
| Creators Name: | Bonhagen, K., Liesenfeld, O., Stadecker, M.J., Hutloff, A., Erb, K., Coyle, A.J., Lipp, M., Kroczek, R.A. and Kamradt, T. |
| Abstract: | T cell activation, differentiation and effector functions depend on signals delivered through the antigen-specific TCR and non-clonal costimulatory receptors on the T cell. Activated T cells express the inducible costimulator (ICOS). We examined the co-expression of ICOS with Th cytokines in mucosal immune responses. ICOS+CD4+ Th cells expressed strikingly different cytokines depending on the type of infection encountered and the cells' anatomical localization. In the Th2-dominated response to Schistosoma mansoni, ICOS expression of CD4+ cells isolated from the liver was strongly associated with the expression of IL-5, IL-10, IL-13, and T1/ST2, but not with the chemokine receptor CXCR5, a pattern consistent with Th2 effector cells. In the secondary lymphatic organs of schistosome-infected mice, ICOS expression was randomly correlated with Th2 effector-cytokines, but positively correlated with CXCR5 expression; a pattern consistent with follicular Th cells. In Th cells isolated from gut or liver of mice infected with Toxoplasma gondii, ICOS expression was positively correlated with IFN-γ production. Finally, in the severe combined immunodeficiency transfer colitis model, ICOS expression was strongly positively associated with IFN-γ and IL-2. Thus, ICOS appears to costimulate distinct effector functions in different immune responses, depending on factors such as the nature of the antigen encountered localization and chronicity of the immune response. |
| Keywords: | Cell Surface Molecule, Mucosa, Parasitic Infection, T Lymphocyte, Th1/Th2 Cell, Animals, Mice |
| Source: | European Journal of Immunology |
| ISSN: | 0014-2980 |
| Publisher: | Wiley |
| Volume: | 33 |
| Number: | 2 |
| Page Range: | 392-401 |
| Date: | February 2003 |
| Official Publication: | https://doi.org/10.1002/immu.200310013 |
| PubMed: | View item in PubMed |
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