Transcriptional profiling identifies Id2 function in dendritic cell development

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Item Type:	Article
Title:	Transcriptional profiling identifies Id2 function in dendritic cell development
Creators Name:	Hacker, C., Kirsch, R.D., Ju, X.S., Hieronymus, T., Gust, T.C., Kuhl, C., Jorgas, T., Kurz, S.M., Rose-John, S., Yokota, Y. and Zenke, M.
Abstract:	Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-specific immune responses. Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo. Id2-/- mice lack Langerhans cells (LCs), the cutaneous contingent of DCs, and the splenic CD8alpha+ DC subset is markedly reduced. Mice deficient for transforming growth factor (TGF)-beta also lack LCs, and we demonstrate here that, in DCs, TGF-beta induces Id2 expression. We also show that Id2 represses B cell genes in DCs. These findings reveal a TGF-beta-Id2 signaling pathway in DCs and suggest a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors.
Keywords:	B-Lymphocytes, Cell Differentiation, DNA-Binding Proteins, Dendritic Cells, Gene Expression Profiling, Inhibitor of Differentiation Protein 2, Oligonucleotide Array Sequence Analysis, Granulocyte-Macrophage Colony-Stimulating Factor Receptors, Interleukin-4 Receptors, Repressor Proteins, Transcription Factors, Transforming Growth Factor beta, Up-Regulation
Source:	Nature Immunology
ISSN:	1529-2908
Publisher:	Nature Publishing Group
Volume:	4
Number:	4
Page Range:	380-386
Date:	April 2003
Official Publication:	https://doi.org/10.1038/ni903
PubMed:	View item in PubMed

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