Establishing a structural genomics platform: The Berlin-based Protein Structure Factory

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Item Type:	Review
Title:	Establishing a structural genomics platform: The Berlin-based Protein Structure Factory
Creators Name:	Heinemann, U.
Abstract:	Structural genomics (structural proteomics) initiatives aiming at the systematic, genome-directed structure analysis of proteins have recently been established in many locations worldwide. As a common international research endeavor, these initiatives thrive at the determination of protein structures representing all sequence families known in the biosphere. To reach this goal, a degree of international coordination of the structural genomics effort, as well as the development of high-throughput structure analysis methods and the provision of suitable research facilities are required. The Protein Structure Factory is a local, Berlin-based structural genomics project aiming at the structure determination of human proteins of presumed structural novelty and medical relevance. This project employs both NMR spectroscopy and X-ray crystallography for protein structure determination and aims at developing automated or semi-automated procedures for protein expression cloning and purification, and NMR spectral assignments. In addition, protein crystallography facilities are being set up at the third-generation synchrotron storage ring BESSY II in Berlin.
Keywords:	Structural Genomics/Proteomics, Protein Structure Analysis, High-Throughput, NMR Spectroscopy, X-ray Crystallography
Source:	Gene Function and Disease
ISSN:	1438-7506
Volume:	3
Number:	1-2
Page Range:	25-32
Date:	October 2002
Official Publication:	https://doi.org/10.1002/1438-826X(200210)3:1/2<25::AID-GNFD25>3.0.CO;2-W

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