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| Item Type: | Review |
|---|---|
| Title: | Establishing a structural genomics platform: The Berlin-based Protein Structure Factory |
| Creators Name: | Heinemann, U. |
| Abstract: | Structural genomics (structural proteomics) initiatives aiming at the systematic, genome-directed structure analysis of proteins have recently been established in many locations worldwide. As a common international research endeavor, these initiatives thrive at the determination of protein structures representing all sequence families known in the biosphere. To reach this goal, a degree of international coordination of the structural genomics effort, as well as the development of high-throughput structure analysis methods and the provision of suitable research facilities are required. The Protein Structure Factory is a local, Berlin-based structural genomics project aiming at the structure determination of human proteins of presumed structural novelty and medical relevance. This project employs both NMR spectroscopy and X-ray crystallography for protein structure determination and aims at developing automated or semi-automated procedures for protein expression cloning and purification, and NMR spectral assignments. In addition, protein crystallography facilities are being set up at the third-generation synchrotron storage ring BESSY II in Berlin. |
| Keywords: | Structural Genomics/Proteomics, Protein Structure Analysis, High-Throughput, NMR Spectroscopy, X-ray Crystallography |
| Source: | Gene Function and Disease |
| ISSN: | 1438-7506 |
| Volume: | 3 |
| Number: | 1-2 |
| Page Range: | 25-32 |
| Date: | October 2002 |
| Official Publication: | https://doi.org/10.1002/1438-826X(200210)3:1/2<25::AID-GNFD25>3.0.CO;2-W |
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