Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

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Item Type:	Article
Title:	Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
Creators Name:	Podar, K., Tai, Y.T., Davies, F.E., Lentzsch, S., Sattler, M., Hideshima, T., Lin, B.K., Gupta, D., Shima, Y., Chauhan, D., Mitsiades, C., Raje, N., Richardson, P. and Anderson, K.C.
Abstract:	Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)-independent Raf-1-MEK-extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM.
Keywords:	Cell Division, Cell Movement, Endothelial Growth Factors, Extracellular Matrix Proteins, Flavonoids, Gene Expression, Plasma Cell Leukemia, Lymphokines, MAP Kinase Kinase 1, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Multiple Myeloma, Protein Kinase C, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-raf, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Cultured Tumor Cells, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors
Source:	Blood
ISSN:	0006-4971
Publisher:	American Society of Hematology
Volume:	98
Number:	2
Page Range:	428-435
Date:	15 July 2001
Official Publication:	https://doi.org/10.1182/blood.V98.2.428
PubMed:	View item in PubMed

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