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| Item Type: | Article |
|---|---|
| Title: | Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension |
| Creators Name: | Rubens, C., Ewert, R., Halank, M., Wensel, R., Orzechowski, H.D., Schultheiss, H.P. and Hoeffken, G. |
| Abstract: | STUDY OBJECTIVES: Primary pulmonary hypertension (PPH) is a rare disease of unknown etiology that is characterized by a poor prognosis. This study was undertaken to investigate possible correlations between endothelin (ET)-1 and big ET-1 plasma levels and the severity of PPH. PATIENTS: Sixteen consecutive patients with PPH were included. INTERVENTIONS: Hemodynamics of patients with PPH were measured by right-heart catheterization, and a 6-min walk test was performed. MEASUREMENTS: Plasma levels of the biologically active peptide ET-1 and its precursor big ET-1 were determined in blood samples from the pulmonary artery, peripheral artery, and peripheral vein by radioimmunoassay. RESULTS: A strong correlation was shown between pulmonary vascular resistance, mean pulmonary artery pressure, cardiac output, cardiac index, 6-min walk data, and elevated plasma levels of big ET-1 as well as mature ET-1 plasma levels at all sites of blood sampling (p < 0.01 and p < 0.05, respectively). CONCLUSIONS: Levels of circulating ET-1 might become a prognostic marker for patients with PPH and serve as a tool for the selection of patients who may benefit from treatment with ET-receptor antagonists. |
| Keywords: | Biological Markers, Blood Pressure, Cardiac Output, Endothelin-1, Endothelins, Hemodynamics, Pulmonary Hypertension, Prognosis, Protein Precursors, Pulmonary Artery, Vascular Resistance |
| Source: | Chest |
| ISSN: | 0012-3692 |
| Publisher: | American College of Chest Physicians |
| Volume: | 120 |
| Number: | 5 |
| Page Range: | 1562-1569 |
| Date: | 1 November 2001 |
| Official Publication: | http://chestjournal.chestpubs.org/content/120/5/1562.abstract |
| PubMed: | View item in PubMed |
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