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| Item Type: | Article |
|---|---|
| Title: | Tenascin-R induces actin-rich microprocesses and branches along neurite shafts |
| Creators Name: | Zacharias, U., Leuschner, R., Noerenberg, U. and Rathjen, F.G. |
| Abstract: | The formation of protrusions along the shaft of neurites might be important in the establishment and refinement of neuronal connections during development. In a search for extracellular signals that affect the formation of microprocesses along neurites we found that the ECM glycoprotein tenascin-R (TN-R) but not other ECM glycoproteins increased the percentage of tectal neurons with actin-rich microprocesses and side branches. Longer actin-based microprocesses were also invaded by microtubuli in their proximal part. The formation of microprocesses by TN-R extending laterally along the neuritic shaft was time- and dose-dependent. In addition to the induction of microprocesses, TN-R increased the size of the growth cone of tectal neurons. A cross-species experiment in combination with blocking antibodies demonstrated that the TN-R-induced effects are mediated by the Ig superfamily member contactin. These observations suggest that TN-R via its neuronal receptor contactin might induce a transition from long-distance growth of tectal interneurons to differentiation, including the formation of microprocesses. |
| Keywords: | Actins, Cell Compartmentation, Cell Differentiation, Cell Size, Cell Surface Receptors, Cultured Cells, Chick Embryo, Growth Cones, Immunohistochemistry, Microtubules, Neurites, Neuronal Cell Adhesion Molecules, Superior Colliculus, Tenascin, Animals |
| Source: | Molecular and Cellular Neuroscience |
| ISSN: | 1044-7431 |
| Publisher: | Academic Press |
| Volume: | 21 |
| Number: | 4 |
| Page Range: | 626-633 |
| Date: | December 2002 |
| Official Publication: | https://doi.org/10.1006/mcne.2002.1203 |
| PubMed: | View item in PubMed |
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