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| Item Type: | Article |
|---|---|
| Title: | Calcium entry through kainate receptors and resulting potassium- channel blockade in Bergmann glial cells |
| Creators Name: | Mueller, T., Moeller, T., Berger, T., Schnitzer-Ungefug, J. and Kettenmann, H. |
| Abstract: | Glutamate receptors, the most abundant excitatory transmitter receptors in the brain, are not restricted to neurons; they have also been detected on glial cells. Bergmann glial cells in mouse cerebellar slices revealed a kainate-type glutamate receptor with a sigmoid current-to-voltage relation, as demonstrated with the patch-clamp technique. Calcium was imaged with fura-2, and a kainate-induced increase in intracellular calcium concentration was observed, which was blocked by the non-N-methyl-D-aspartate (NMDA) glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and by low concentrations of external calcium, indicating that there was an influx of calcium through the kainate receptor itself. The entry of calcium led to a marked reduction in the resting (passive) potassium conductance of the cell. Purkinje cells, which have glutamatergic synapses, are closely associated with Bergmann glial cells and therefore may provide a functionally important stimulus. |
| Keywords: | Biological Transport, Calcium, Cerebellum, Electric Conductivity, Ion Channel Gating, Ionomycin, Kainic Acid, Neuroglia, Potassium Channels, Kainic Acid Receptors, Neurotransmitter Receptors, Animals, Mice |
| Source: | Science |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 256 |
| Number: | 5063 |
| Page Range: | 1563-1566 |
| Date: | 12 June 1992 |
| Official Publication: | https://doi.org/10.1126/science.1317969 |
| PubMed: | View item in PubMed |
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