Cytochrome P-450-CO and substrates: lessions from ligand binding under high pressure

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Item Type:	Review
Title:	Cytochrome P-450-CO and substrates: lessions from ligand binding under high pressure
Creators Name:	Jung, C.
Abstract:	An overview of the application of high-pressure studies on the carbon monoxide complex of cytochrome P-450 is given. Different approaches to characterize ligand binding steps, the conformational states and substates and the compressibility of the ligand-bound complex are reviewed. A particular focus is the effect of substrates on these properties. It is shown that substrate mobility, compressibility and water accessibility are interrelated and may have functional meaning.
Keywords:	Compressibility, Cytochrome P-450, Fourier Transform Infrared Spectroscopy, High Pressure, Ligand binding, UV-Visible Spectroscopy
Source:	Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology
ISSN:	0167-4838
Publisher:	Elsevier
Volume:	1595
Number:	1-2
Page Range:	309-328
Date:	1 January 2002
PubMed:	View item in PubMed

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