Identification of functional domains and evolution of Tc1-like transposable elements

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Item Type:	Article
Title:	Identification of functional domains and evolution of Tc1-like transposable elements
Creators Name:	Ivics, Z., Izsvak, Z., Minter, A. and Hackett, P.B.
Abstract:	Tc1-like transposable elements from teleost fish have been phylogenetically examined to determine the mechanisms involved in their evolution and conserved domains of function. We identified two new functional domains in these elements. The first is a bipartite nuclear localization signal, indicating that transposons can take advantage of the transport machinery of host cells for nuclear uptake of their transposases. The second is a novel combination of a paired domain-related protein motif juxtaposed to a leucine zipper-like domain located in the putative DNA-binding regions of the transposases. This domain coexists with a special inverted repeat structure in certain transposons in such phylogenetically distant hosts as fish and insects. Our data indicate that reassortment of functional domains and horizontal transmission between species are involved in the formation and spread of new types of transposable elements.
Keywords:	Amino Acid Sequence, Cell Line, Conserved Sequence, DNA Transposable Elements, DNA-Binding Proteins, Drosophila, Molecular Evolution, Leucine Zippers, Molecular Sequence Data, Nucleotidyltransferases, Phylogeny, Amino Acid Sequence Homology, Transfection, Transposases, Animals, Fishes, Mice
Source:	Proceedings of the National Academy of Sciences of the United States of America
ISSN:	0027-8424
Publisher:	National Academy of Sciences
Volume:	93
Number:	10
Page Range:	5008-5013
Date:	14 May 1996
Official Publication:	https://doi.org/10.1073/pnas.93.10.5008
PubMed:	View item in PubMed

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