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| Item Type: | Article |
|---|---|
| Title: | Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus |
| Creators Name: | Ueno, T., Hara, K., Willis, M.S., Malin, M.A., Höpken, U.E., Gray, D.H.D., Matsushima, K., Lipp, M., Springer, T.A., Boyd, R.L., Yoshie, O. and Takahama, Y. |
| Abstract: | Most T lymphocytes are generated within the thymus. It is unclear, however, how newly generated T cells relocate out of the thymus to the circulation. The present study shows that a CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture. Another CC chemokine CCL21, which shares CCR7 with CCL19 but has a unique C-terminal extension containing positively charged amino acids, failed to show involvement in thymic emigration. Neonatal appearance of circulating T cells was defective in CCL19-neutralized mice as well as in CCR7-deficient mice but not in CCL21-neutralized mice. In the thymus, CCL19 is predominantly localized in the medulla including endothelial venules. These results indicate a CCL19- and CCR7-dependent pathway of thymic emigration, which represents a major pathway of neonatal T cell export. |
| Keywords: | CC Chemokines, Chemokine Receptors, Chemotaxis, Gene Expression, Knockout Mice, Ligands, Neutralization Tests, Newborn Animals, Organ Culture Techniques, T-Lymphocytes, Thymus Gland, Animals, Mice |
| Source: | Immunity |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Volume: | 16 |
| Number: | 2 |
| Page Range: | 205-218 |
| Date: | 1 January 2002 |
| Official Publication: | https://doi.org/10.1016/S1074-7613(02)00267-4 |
| PubMed: | View item in PubMed |
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