Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

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Item Type:	Article
Title:	Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus
Creators Name:	Ueno, T., Hara, K., Willis, M.S., Malin, M.A., Höpken, U.E., Gray, D.H.D., Matsushima, K., Lipp, M., Springer, T.A., Boyd, R.L., Yoshie, O. and Takahama, Y.
Abstract:	Most T lymphocytes are generated within the thymus. It is unclear, however, how newly generated T cells relocate out of the thymus to the circulation. The present study shows that a CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture. Another CC chemokine CCL21, which shares CCR7 with CCL19 but has a unique C-terminal extension containing positively charged amino acids, failed to show involvement in thymic emigration. Neonatal appearance of circulating T cells was defective in CCL19-neutralized mice as well as in CCR7-deficient mice but not in CCL21-neutralized mice. In the thymus, CCL19 is predominantly localized in the medulla including endothelial venules. These results indicate a CCL19- and CCR7-dependent pathway of thymic emigration, which represents a major pathway of neonatal T cell export.
Keywords:	CC Chemokines, Chemokine Receptors, Chemotaxis, Gene Expression, Knockout Mice, Ligands, Neutralization Tests, Newborn Animals, Organ Culture Techniques, T-Lymphocytes, Thymus Gland, Animals, Mice
Source:	Immunity
ISSN:	1074-7613
Publisher:	Cell Press
Volume:	16
Number:	2
Page Range:	205-218
Date:	1 January 2002
Official Publication:	https://doi.org/10.1016/S1074-7613(02)00267-4
PubMed:	View item in PubMed

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