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| Item Type: | Article |
|---|---|
| Title: | Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices |
| Creators Name: | Schmidt-Ullrich, R., Aebischer, T., Huelsken, J., Birchmeier, W., Klemm, U. and Scheidereit, C. |
| Abstract: | NF-κB/Rel transcription factors and IκB kinases (IKK) are essential for inflammation and immune responses, but also for bone-morphogenesis, skin proliferation and differentiation. Determining their other functions has previously been impossible, owing to embryonic lethality of NF-κB/Rel or IKK-deficient animals. Using a gene targeting approach we have ubiquitously expressed an NF-κB super-repressor to investigate NF-κB functions in the adult. Mice with suppressed NF-κB revealed defective early morphogenesis of hair follicles, exocrine glands and teeth, identical to Eda (tabby) and Edar (downless) mutant mice. These affected epithelial appendices normally display high NF-κB activity, suppression of which resulted in increased apoptosis, indicating that NF-κB acts as a survival factor downstream of the tumor necrosis factor receptor family member EDAR. Furthermore, NF-κB is required for peripheral lymph node formation and macrophage function. |
| Keywords: | Cre-loxP, Drug Targeting, Hypohidrotic Ectodermal Dysplasia (HED), Immunity, Mouse, Skin Disease, Animals, Mice |
| Source: | Development |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Volume: | 128 |
| Number: | 19 |
| Page Range: | 3843-3853 |
| Date: | 1 January 2001 |
| Official Publication: | http://dev.biologists.org/cgi/content/abstract/128/19/3843 |
| PubMed: | View item in PubMed |
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