The impact of c-met/scatter factor receptor on dendritic cell migration

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Item Type:	Article
Title:	The impact of c-met/scatter factor receptor on dendritic cell migration
Creators Name:	Kurz, S.M., Diebold, S.S., Hieronymus, T., Gust, T.C., Bartunek, P., Sachs, M., Birchmeier, W. and Zenke, M.
Abstract:	Dendritic cells (DC) are professional antigen-presenting cells that possess both migratory properties and potent T cell stimulatory activity, and that allow the uptake of antigenic material in peripheral tissues and its subsequent presentation in the T cell areas of lymphoid organs. Thus motility represents a central property that is required for DC function. Here we report on the expression of the receptor tyrosine kinase c-met in DC. c-Met is the high affinity receptor for scatter factor (SF)/hepatocyte growth factor, and ligand-activated c-met exhibits mitogenic, morphogenic and motogenic activity in vivo and in vitro. c-Met is signaling competent in DC since it is effectively tyrosine phosphorylated in response to SF ligand. It is demonstrated here that ligand-activated c-met regulates DC adhesion to the extracellular matrix component laminin but leaves antigen presenting function unaffected. Importantly, in ear sheet explant experiments activation of c-met by ligand induces emigration of cutaneous DC (Langerhans cell, LC) from skin, but SF is not a chemoattractant factor for DC. Our results suggest an important role of the c-met/SF system in DC/LC migration.
Keywords:	Antigen Presentation, c-Met, Dendritic Cell, Migration, Scatter Factor, Animals, Mice
Source:	European Journal of Immunology
ISSN:	0014-2980
Publisher:	Wiley
Volume:	32
Number:	7
Page Range:	1832-1838
Date:	1 January 2002
Official Publication:	https://doi.org/10.1002/1521-4141(200207)32:7<1832::AID-IMMU1832>3.0.CO;2-2
PubMed:	View item in PubMed

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