Neuronal calcium stores

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Item Type:	Review
Title:	Neuronal calcium stores
Creators Name:	Verkhratsky, A.J. and Petersen, O.H.
Abstract:	Neuronal calcium stores associated with specialized intracellular organelles, such as endoplasmic reticulum and mitochondria, dynamically participate in generation of cytoplasmic calcium signals which accompany neuronal activity. They fulfil a dual role in neuronal Ca2+ homeostasis being involved in both buffering the excess of Ca2+ entering the cytoplasm through plasmalemmal channels and providing an intracellular source for Ca2+. Increase of Ca2+ content within the stores regulates the availability and magnitude of intracellular calcium release, thereby providing a mechanism which couples the neuronal activity with functional state of intracellular Ca2+ stores. Apart of 'classical' calcium stores (endoplasmic reticulum and mitochondria) other organelles (e.g. nuclear envelope and neurotransmitter vesicles) may potentially act as a functional Ca2+ storage compartments. Calcium ions released from internal stores participate in many neuronal functions, and might be primarily involved in regulation of various aspects of neuronal plasticity.
Keywords:	Calcium, Calcium Signaling, Endoplasmic Reticulum, Mitochondria, Neurons, Animals
Source:	Cell Calcium
ISSN:	0143-4160
Publisher:	Elsevier
Volume:	24
Number:	5-6
Page Range:	333-343
Date:	1 November 1998
Official Publication:	https://doi.org/10.1016/S0143-4160(98)90057-4
PubMed:	View item in PubMed

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