Impact of plasma p-tau181 on cognition, motor phenotypes, and disease course in ALS

Kasper, Elisabeth; Lehto, Annaliis; Nordmann, Nina; Peters, Oliver; Hellmann, Julian; Priller, Josef; Spruth, Eike Jakob; Petzold, Gabor C.; Vogt, Ina; Weydt, Patrick; Bernsen, Sarah; Dinter, Elisabeth; Falkenburger, Björn; Günther, René; Düzel, Emrah; Glanz, Wenzel; Synofzik, Matthis; Beichert, Lukas; Spottke, Annika; Wagner, Michael; Brosseron, Frederic; Schmid, Matthias C.; Schneider, Anja; Teipel, Stefan; Prudlo, Johannes; Hermann, Andreas

Impact of plasma p-tau181 on cognition, motor phenotypes, and disease course in ALS

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Item Type:	Article
Title:	Impact of plasma p-tau181 on cognition, motor phenotypes, and disease course in ALS
Creators Name:	Kasper, Elisabeth, Lehto, Annaliis, Nordmann, Nina, Peters, Oliver, Hellmann, Julian, Priller, Josef, Spruth, Eike Jakob, Petzold, Gabor C., Vogt, Ina, Weydt, Patrick, Bernsen, Sarah, Dinter, Elisabeth, Falkenburger, Björn, Günther, René, Düzel, Emrah, Glanz, Wenzel, Synofzik, Matthis, Beichert, Lukas, Spottke, Annika, Wagner, Michael, Brosseron, Frederic, Schmid, Matthias C., Schneider, Anja, Teipel, Stefan, Prudlo, Johannes and Hermann, Andreas
Abstract:	Phosphorylated tau181 (p-tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p-tau181 in 202 ALS/ALS-FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics. Plasma p-tau181 and NfL were significantly elevated in ALS, with p-tau181 increasing over 1 year while NfL remained stable. Neither marker correlated with cognitive performance, and only NfL was associated with disease severity and progression. Plasma p-tau181 was higher in patients with predominant lower motor neuron involvement. The results indicate that p-tau181 reflects peripheral processes in ALS, providing a complementary, mechanistically distinct biomarker from NfL.
Keywords:	Alzheimer Disease, Amyotrophic Lateral Sclerosis, Plasma p-tau181
Source:	Annals of Clinical and Translational Neurology
ISSN:	2328-9503
Publisher:	Wiley
Date:	4 May 2026
Official Publication:	https://doi.org/10.1002/acn3.70423
PubMed:	View item in PubMed

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