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| Item Type: | Article |
|---|---|
| Title: | Impact of plasma p-tau181 on cognition, motor phenotypes, and disease course in ALS |
| Creators: |
Kasper, Elisabeth  ORCID: https://orcid.org/0000-0003-0583-1236, Lehto, Annaliis, Nordmann, Nina, Peters, Oliver ORCID: https://orcid.org/0000-0003-0568-2998, Hellmann, Julian ORCID: https://orcid.org/0000-0003-0411-9204, Priller, Josef ORCID: https://orcid.org/0000-0001-7596-0979, Spruth, Eike Jakob, Petzold, Gabor C. ORCID: https://orcid.org/0000-0002-0145-8641, Vogt, Ina, Weydt, Patrick, Bernsen, Sarah, Dinter, Elisabeth, Falkenburger, Björn, Günther, René, Düzel, Emrah, Glanz, Wenzel, Synofzik, Matthis, Beichert, Lukas ORCID: https://orcid.org/0009-0000-9259-9230, Spottke, Annika, Wagner, Michael, Brosseron, Frederic, Schmid, Matthias C., Schneider, Anja, Teipel, Stefan ORCID: https://orcid.org/0000-0002-3586-3194, Prudlo, Johannes ORCID: https://orcid.org/0000-0002-7932-5929 and Hermann, Andreas ORCID: https://orcid.org/0000-0002-7364-7791
|
| Abstract: | Phosphorylated tau181 (p-tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p-tau181 in 202 ALS/ALS-FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics. Plasma p-tau181 and NfL were significantly elevated in ALS, with p-tau181 increasing over 1 year while NfL remained stable. Neither marker correlated with cognitive performance, and only NfL was associated with disease severity and progression. Plasma p-tau181 was higher in patients with predominant lower motor neuron involvement. The results indicate that p-tau181 reflects peripheral processes in ALS, providing a complementary, mechanistically distinct biomarker from NfL. |
| Keywords: | Alzheimer Disease, Amyotrophic Lateral Sclerosis, Plasma p-tau181 |
| Source: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Publisher: | Wiley |
| Date: | 4 May 2026 |
| Official Publication: | https://doi.org/10.1002/acn3.70423 |
| PubMed: | View item in PubMed |
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