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| Item Type: | Review |
|---|---|
| Title: | The history and function of a circular RNA |
| Creators Name: | Cerda-Jara, Cledi A., Scoyni, Flavia, Zolotarov, Grygoriy, Bhaskar, Poojashree, León-Periñán, Daniel, Kjems, Jørgen and Rajewsky, Nikolaus |
| Abstract: | Cdr1as/ciRS-7 is a circular RNA conserved in mammals and highly expressed in brain. It features a large number of microRNA target sites bound in vivo by miR-7/miR-671. Cdr1as regulates synaptic activity under stress in a temporal, spatial, and neuron-specific manner. We review genetic, molecular, evolutionary, and physiological data to discuss how Cdr1as and its interactors form a functionally important network of non-coding RNAs that regulates neuronal adaptability. We provide a framework to explore potential roles of other non-coding RNA networks on brain function and their diagnostic and therapeutic potential. |
| Keywords: | Brain, Circular RNA, Long Noncoding RNA, MicroRNAs, Neurons, RNA, Animals |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 17 |
| Number: | 1 |
| Page Range: | 3862 |
| Date: | 28 April 2026 |
| Official Publication: | https://doi.org/10.1038/s41467-026-71822-0 |
| PubMed: | View item in PubMed |
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