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Better than average: spatially-aware aggregation of segmentation uncertainty improves downstream performance

Item Type:Preprint
Title:Better than average: spatially-aware aggregation of segmentation uncertainty improves downstream performance
Creators Name:Guarino, Vanessa Emanuela, Winklmayr, Claudia, Franzen, Jannik, Rumberger, Josef Lorenz, Pfeuffer, Manuel, Greven, Sonja, Maier-Hein, Klaus, Lüth, Carsten T., Karg, Christoph and Kainmueller, Dagmar
Abstract:Uncertainty Quantification (UQ) is crucial for ensuring the reliability of automated image segmentations in safetycritical domains like biomedical image analysis or autonomous driving. In segmentation, UQ generates pixelwise uncertainty scores that must be aggregated into imagelevel scores for downstream tasks like Out-of-Distribution (OoD) or failure detection. Despite routine use of aggregation strategies, their properties and impact on downstream task performance have not yet been comprehensively studied. Global Average is the default choice, yet it does not account for spatial and structural features of segmentation uncertainty. Alternatives like patch-, class- and thresholdbased strategies exist, but lack systematic comparison, leading to inconsistent reporting and unclear best practices. We address this gap by (1) formally analyzing properties, limitations, and pitfalls of common strategies; (2) proposing novel strategies that incorporate spatial uncertainty structure and (3) benchmarking their performance on OoD and failure detection across ten datasets that vary in image geometry and structure. We find that aggregators leveraging spatial structure yield stronger performance in both downstream tasks studied. However, the performance of individual aggregators depends heavily on dataset characteristics, so we (4) propose a meta-aggregator that integrates multiple aggregators and performs robustly across datasets.
Source:arXiv
Publisher:Cornell University
Article Number:2603.29941
Date:31 March 2026
Official Publication:https://doi.org/10.48550/arXiv.2603.29941
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