Do metabolic fluxes change with age?

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Item Type:	Editorial
Title:	Do metabolic fluxes change with age?
Creators Name:	Hofer, Sebastian J., Simon, Anna Katharina and Madeo, Frank
Abstract:	Metabolomes change with age. Yet, fluxomics points to a contradiction: Jankowski et al. in Cell Metabolism report shifts in metabolite concentrations in aged mice, alongside largely preserved metabolite fluxes, evoking important questions on the nature of age-related metabolic disturbances. We discuss how this might recalibrate our understanding of aging metabolism.
Keywords:	Metabolism, Geroscience, Aging, Age-Associated Diseases, Autophagy, Animals, Mice
Source:	Trends in Endocrinology and Metabolism
ISSN:	1043-2760
Publisher:	Elsevier
Date:	17 March 2026
Official Publication:	https://doi.org/10.1016/j.tem.2026.01.013
PubMed:	View item in PubMed

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