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| Item Type: | Article |
|---|---|
| Title: | Takotsubo-Syndrom: Kann die Grundlagenwissenschaft helfen? [Takotsubo syndrome: can basic science help?] |
| Creators Name: | Bruns, Bastian, Frey, Norbert and Backs, Johannes |
| Abstract: | Takotsubo syndrome (TTS) is a stress-associated acute heart failure mimicking the clinical features of acute myocardial infarction. Elevated catecholamine levels appear to play a pivotal role in the pathogenesis. Despite rapid recovery of systolic left ventricular function in most cases the acute and/or long-term prognosis is often limited depending mostly on the clinical risk profile. A pathophysiology-oriented treatment does not yet exist due to the lack of evidence-based strategies; however, basic research has identified several possible mechanisms beyond a purely catecholamine hypothesis. This includes, for example, an apical beta-2-adrenoceptor mediated myocardial inhibition, a microvascular, mitochondrial or metabolic dysfunction as well as myocardial inflammation. In a translational approach, based on experimental data, the inhibition of the calcineurin signalling pathway as the driver of TTS is currently being investigated in the acute setting in a randomized double-blind phase II clinical study. This article, for example, discusses how basic science can contribute to the identification of important aspects of the pathophysiology and translation of causal treatment strategies. |
| Keywords: | Broken Heart, Cyclosporine A, Akute Herzinsuffizienz, Inflammation, Repurposing |
| Source: | Kardiologie |
| ISSN: | 2731-7129 |
| Publisher: | Springer |
| Date: | 24 February 2026 |
| Official Publication: | https://doi.org/10.1007/s12181-026-00802-x |
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