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| Item Type: | Article |
|---|---|
| Title: | 3D whole-kidney T(1) mapping using look-locker inversion recovery in conjunction with balanced SSFP readout and dictionary matching |
| Creators Name: | Zhang, Wenyan, Chen, Zelong, Tao, Quan, Li, Caixia, Wang, Jianping, Zhang, Yizhe, Xie, Di, Ma, Jianhua, Niendorf, Thoralf and Feng, Yanqiu |
| Abstract: | PURPOSE: To develop and validate dual breath-hold Look-Locker inversion recovery (Dual 3DLL) MRI for 3D whole-kidney T(1) quantification using dictionary matching. METHODS: Dual 3DLL employs two breath-hold Look-Locker prepared acquisitions using nonselective adiabatic inversion in conjunction with 3D balanced SSFP readouts at three inversion times for each breath-hold. Retrospective registration of T(1)-weighted images was implemented to reduce misalignment between two breath-holds. For T(1) quantification, Bloch equation-based dictionary matching was applied. Dual 3DLL was validated in phantoms using inversion recovery spin-echo (IRSE) based T(1) mapping as a reference and in 11 healthy subjects, where 2D MOLLI-based renal T(1) mapping was used as a reference. RESULTS: Validation in the phantom showed an agreement between Dual 3DLL and IRSE (precision: coefficient of variation = 2.5%, relative error compared to IRSE: 4.3% ± 2.0%). The human feasibility study demonstrated the clinical applicability of Dual 3DLL. Averaged T(1) derived from whole-kidney coverage Dual 3DLL was in accordance with that of 2D MOLLI (renal cortex: T(1,Dual 3DLL) = 1413.41 ± 114.73 ms, T(1,MOLLI) = 1394.39 ± 58.01 ms; medulla: T(1,Dual 3DLL) = 1827.48 ± 108 ms, T(1,MOLLI) = 1843.67 ± 91.54 ms). The coefficients of variation between T(1) obtained from Dual 3DLL and MOLLI were 6.1% for the renal cortex and 4.4% for the medulla. CONCLUSION: This study demonstrates the feasibility of 3D whole kidney T(1) mapping using dual breath-hold Look-Locker T(1)-weighting in conjunction with balanced SSFP readouts and dictionary matching, and provides a technical foundation for improving our understanding of renal (patho-)physiology. |
| Keywords: | Inversion Recovery, Kidney, Magnetic Resonance Imaging, T(1) Quantification, Whole-Kidney Coverage |
| Source: | Magnetic Resonance in Medicine |
| ISSN: | 0740-3194 |
| Publisher: | Wiley |
| Date: | 27 February 2026 |
| Official Publication: | https://doi.org/10.1002/mrm.70321 |
| PubMed: | View item in PubMed |
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