Systematic review of international population studies with cardiac magnetic resonance and genomics research data ("Imagenomics")

Hesse, Kerrick; Aung, Nay; Petersen, Steffen E.; Siripanthong, Bhurint; Captur, Gabriella; Yeo, Khung Keong; Friedrich, Matthias G.; Jaddoe, Vincent W.V.; Dörr, Marcus; Pischon, Tobias; Bluemke, David A.; Ibáñez, Borja; Fuster, Valentin; Chahal, C. Anwar A.; Khanji, Mohammed Y.

Systematic review of international population studies with cardiac magnetic resonance and genomics research data ("Imagenomics")

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Item Type:	Review
Title:	Systematic review of international population studies with cardiac magnetic resonance and genomics research data ("Imagenomics")
Creators Name:	Hesse, Kerrick, Aung, Nay, Petersen, Steffen E., Siripanthong, Bhurint, Captur, Gabriella, Yeo, Khung Keong, Friedrich, Matthias G., Jaddoe, Vincent W.V., Dörr, Marcus, Pischon, Tobias, Bluemke, David A., Ibáñez, Borja, Fuster, Valentin, Chahal, C. Anwar A. and Khanji, Mohammed Y.
Abstract:	Epidemiological population studies may include cardiac magnetic resonance (CMR)-derived phenotyping and large-scale genotyping, providing unprecedented level of detail to investigate novel gene-lifestyle-disease interactions. The systematic review presents high-level summaries and critically appraises contemporary challenges and biobank opportunities. The authors identified 17 relevant biobanks by searching "CMR," "genome" and "population study" on MEDLINE, EMBASE, and Web of Science 2025. Collectively, studies recruited ∼1 million participants with stored blood samples for extensive genomic analyses, of whom >180,000 have or will undergo CMR. Use of expansive personal data must safeguard participant confidentiality, encourage technological standardization, and champion inclusivity and sustainability. Application of genotypic and imaging-derived phenotypic information will be readily translatable to clinical practice through investigation of, among others, new therapeutic targets and highly sensitive and specific biomarkers. Imaging biobanks are accessible to researchers by application. This systematic review should inspire greater use and cross-collaboration and facilitate powerful discoveries in more heterogeneous population samples.
Keywords:	Cardiovascular Magnetic Resonance, Genomics, Population Study
Source:	JACC: Cardiovascular Imaging
ISSN:	1936-878X
Publisher:	Elsevier
Date:	27 February 2026
Official Publication:	https://doi.org/10.1016/j.jcmg.2026.01.007
PubMed:	View item in PubMed

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