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| Item Type: | Dataset |
|---|---|
| Title: | Clonally expanded effector CD4+ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy |
| Creators: |
Maschmeyer, P.  ORCID: https://orcid.org/0000-0002-1705-5302, Giguelay, A.M. ORCID: https://orcid.org/0000-0003-0417-1109 and Ludwig, L.S. ORCID: https://orcid.org/0000-0002-2916-2164
|
| Abstract: | Immune checkpoint inhibitor (ICI) therapies present a pillar of modern cancer therapy but can cause severe and potentially fatal neurological immune-related adverse events (n-irAEs). Here, we performed single-cell RNA sequencing and T cell receptor profiling of PBMCs of a cohort of 17 cancer patients receiving ICI therapy. Our data suggest alterations in regulatory T cell frequencies and B cell states, and a significant enrichment of clonally expanded CD4+ cytotoxic T lymphocytes (CD4+ CTLs) with an effector gene expression profile in n-irAE patients. |
| Source: | Gene Expression Omnibus (GEO) |
| Publisher: | National Center for Biotechnology Information (NCBI) |
| Date: | 3 December 2025 |
| External Fulltext: | View full text on external repository or document server |
| Related to: |
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