Clonally expanded effector CD4+ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy

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Title:	Clonally expanded effector CD4+ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy
Creators Name:	Maschmeyer, P., Giguelay, A.M. and Ludwig, L.S.
Abstract:	Immune checkpoint inhibitor (ICI) therapies present a pillar of modern cancer therapy but can cause severe and potentially fatal neurological immune-related adverse events (n-irAEs). Here, we performed single-cell RNA sequencing and T cell receptor profiling of PBMCs of a cohort of 17 cancer patients receiving ICI therapy. Our data suggest alterations in regulatory T cell frequencies and B cell states, and a significant enrichment of clonally expanded CD4+ cytotoxic T lymphocytes (CD4+ CTLs) with an effector gene expression profile in n-irAE patients.
Source:	Gene Expression Omnibus (GEO)
Publisher:	National Center for Biotechnology Information (NCBI)
Date:	3 December 2025
External Fulltext:	View full text on external repository or document server
Related to:	URL URL Type https://edoc.mdc-berlin.de/25869/ Publication https://edoc.mdc-berlin.de/26205/ Dataset

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