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| Item Type: | Article |
|---|---|
| Title: | Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity |
| Creators Name: | Ostendorf, Benjamin N., Goldstein, Jonathan G., Liu, Shuang, Gonsalves, Foster C., Bilanovic, Jana, Yuan, Mathias, Kim, Ji-Young, Rouya, Christopher, Tavazoie, Masoud and Tavazoie, Sohail F. |
| Abstract: | Many cancer patients do not benefit from current immunotherapies. This lack of efficacy may be, in part, due to insufficient priming and activation of T cells. Here, we show that activation of liver-X-receptors (LXRs) promotes adaptive anti-tumor immunity by enhancing priming of T cells. Genetic LXR deletion in the host and depletion of dendritic and CD8+ T cells, but not of macrophages, abrogated anti-tumor effects of LXR-agonistic therapy. In cross-presentation assays, LXR agonism promoted T cell activation upon DC/T cell cross talk. Genetic deletion of LXRs in T cells, but not in dendritic cells, blunted this effect. Dissection of the temporal dynamics of LXR-enhanced T cell effector function showed that LXR agonism rendered T cells more receptive to adopting effector states upon stimulation. Consistently, LXR agonist therapy elicited T cell expansion in cancer patients enrolled in a phase I trial. Our findings establish LXR activation as an effective approach for enhancing T cell priming. |
| Keywords: | CD8-Positive T-Lymphocytes, Cross-Priming, Dendritic Cells, Inbred C57BL Mice, Knockout Mice, Liver X Receptors, Lymphocyte Activation, Neoplasms, T-Lymphocytes, Animals, Mice |
| Source: | Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Volume: | 223 |
| Number: | 4 |
| Page Range: | e20252290 |
| Date: | 6 April 2026 |
| Official Publication: | https://doi.org/10.1084/jem.20252290 |
| PubMed: | View item in PubMed |
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