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| Item Type: | Article |
|---|---|
| Title: | A simulation procedure for stereological correction of early AMD lesion sizes observed in single OCT-B-scans |
| Creators Name: | Wagner, Marcus, Leutloff, Carla J. and Rauscher, Franziska G. |
| Abstract: | PURPOSE: Early lesions caused by age-related macular degeneration (AMD) are imaged by optical coherence tomography (OCT) in unprecedented detail. Most probably, however, the sampling plane of an OCT scan meets a given lesion noncentrally, and the observed sizes of its diameter, cross-sectional area, and volume must be stereologically corrected. METHODS: Stereological corrections are obtained by a simulation procedure, which is applied to the leading scans in a consecutive sample of 100 early AMD participants. RESULTS: Mean corrections for lesion diameter, cross-sectional area and volume amount to +9.1%, +32.0%, and +46.6%, respectively. After correction, AMD stage classifications with respect to the 125-µm diameter cutpoint had to be changed for seven participants. CONCLUSIONS: Simulation results confirm that for lesions pictured and measured in OCT scans - regardless of the accuracy of OCT imaging - stereological correction of observed sizes is compelling and unavoidable. TRANSLATIONAL RELEVANCE: Categorial AMD classifications based on observed OCT data must be reexaminated after stereological correction. |
| Keywords: | Age-Related Macular Degeneration, Observed Lesion Size, Optical Coherence Tomography, Simulation Procedure, Stereological Correction |
| Source: | Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Publisher: | Association for Research in Vision and Opthalmology |
| Volume: | 15 |
| Number: | 1 |
| Page Range: | 21 |
| Date: | January 2026 |
| Official Publication: | https://doi.org/10.1167/tvst.15.1.21 |
| PubMed: | View item in PubMed |
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