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| Item Type: | Article |
|---|---|
| Title: | The dorsal aortic compartment is a developmental source of brown adipose tissue in mice |
| Creators Name: | Heider, Sophie, Fischer, Cornelius, Secener, Ali Kerim, Vallecillo-Garcı́a, Pedro, Kotsaris, Georgios, Meisen, Zarah G., Pawolski, Verena, Giesecke-Thiel, Claudia, Conrad, Thomas, Schulz, Tim J., Sauer, Sascha and Stricker, Sigmar |
| Abstract: | White adipose tissue primarily stores energy while brown adipose tissue dissipates energy as heat, holding promise for therapeutic use. Brown adipose tissue in the anterior trunk is believed to derive from the somitic mesoderm, although some depots are of partially unknown origin. Here we show that the subscapular, lateral, cervical and peri-aortic brown adipose depots, but not the interscapular depot, are in part formed by a non-somitic source. Single-cell sequencing along with genetic lineage tracing indicates that at embryonic day 9.5 the dorsal aorta compartment harbors multipotent mesenchymal progenitors expressing the transcription factor Osr1. Spreading laterally from the dorsal aortic midline, these cells contribute to adipose, cartilage and myogenic lineages. This study uncovers an alternative source of brown adipose tissue and suggests that a fraction of dorsal aorta-associated mesenchymal Osr1(+) cells may represent the in vivo correlate of a multipotent progenitor cell type so far only characterized in vitro, the mesoangioblast. |
| Keywords: | Aorta, Brown Adipose Tissue, Cell Differentiation, Cell Lineage, Developmental Gene Expression Regulation, Inbred C57BL Mice, Mesenchymal Stem Cells, Mesoderm, Single-Cell Analysis, Transcription Factors, White Adipose Tissue, Animals, Mice |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 17 |
| Number: | 1 |
| Page Range: | 286 |
| Date: | 8 January 2026 |
| Official Publication: | https://doi.org/10.1038/s41467-025-68147-9 |
| PubMed: | View item in PubMed |
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