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| Item Type: | Article |
|---|---|
| Title: | 血液透析对外周组织中氧代二十碳四烯酸生物转化的影响 [Effect of hemodialysis on the biotransformation of oxo-eicosatetraenoic acids in peripheral tissues] |
| Creators Name: | Liu, Tong, Gollasch, Maik, Luft, Friedrich C., Lin, Pan, Ji, Jun and Meng, Yao |
| Abstract: | OBJECTIVE: To analyze the differences of free and esterified oxo-eicosatetraenoic acids (oxo-ETEs) in blood cells and plasma from arterial and venous blood in hemodialysis (HD) patients. METHODS: Arterial and venous blood samples from 12 patients with end-stage renal disease (ESRD) before and after HD treatment at Charité – Universitätsmedizin Berlin, Germany, from June to December 2020 were collected. The esterified and free oxo-ETEs derived from arachidonic acid in blood cells and plasma were measured by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). RESULTS: Neither esterified nor free oxo-ETEs in blood cells displayed significant arteriovenous differences before and after HD. HD predominantly affected the metabolic levels of esterified and free oxo-ETEs in plasma. HD reduced the arteriovenous differences of esterified 12-oxo-ETE, free 15-oxo-ETE, and free 5-oxo-ETE in plasma, while raised the arteriovenous differences of esterified 15-oxo-ETE. CONCLUSIONS: The oxo-ETEs in blood cells are relatively well-stabilized responding to HD treatment, whereas arteriovenous differences of free and esterified oxo-ETEs in plasma are present and active in response to HD treatment, potentially contributing to the cardiovascular disease. |
| Source: | Chinese Journal of Clinical Medicine |
| ISSN: | 1008-6358 |
| Publisher: | Shanghai Chinese Clinical Medicine Press |
| Volume: | 32 |
| Number: | 1 |
| Page Range: | 93-100 |
| Date: | 24 February 2025 |
| Official Publication: | http://doi.org/10.12025/j.issn.1008-6358.2025.20241213 |
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