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| Item Type: | Comment |
|---|---|
| Title: | Similar and yet not quite the same: unmasking distinct type I interferon signatures in ANCA vasculitis |
| Creators Name: | Kling, Lovis and Kettritz, Ralph |
| Abstract: | Antineutrophil cytoplasmic autoantibody–associated vasculitides can be classified by clinical phenotype or antineutrophil cytoplasmic autoantibody specificity, with overlapping yet distinct characteristics. Transcriptomic analyses of kidney biopsies from 2 French antineutrophil cytoplasmic autoantibody–associated vasculitis (AAV) cohorts revealed a pronounced type I interferon signature in microscopic polyangiitis (microscopic polyangiitis/myeloperoxidaseAAV) compared with granulomatosis with polyangiitis (granulomatosis with polyangiitis/proteinase 3-AAV). Among biopsies with high interferon scores, 66% were myeloperoxidase-AAV and 28% proteinase 3-AAV. The interferon score was associated with decreased kidney survival. These findings highlight AAV patient heterogeneity and support targeted treatment approaches. |
| Keywords: | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Antineutrophil Cytoplasmic Antibodies, Biopsy, France, Gene Expression Profiling, Granulomatosis with Polyangiitis, Interferon Type I, Kidney, Microscopic Polyangiitis, Myeloblastin, Peroxidase, Transcriptome |
| Source: | Kidney International |
| ISSN: | 0085-2538 |
| Publisher: | Elsevier / International Society of Nephrology |
| Volume: | 109 |
| Number: | 1 |
| Page Range: | 34-37 |
| Date: | January 2026 |
| Official Publication: | https://doi.org/10.1016/j.kint.2025.10.002 |
| PubMed: | View item in PubMed |
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