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| Item Type: | Article |
|---|---|
| Title: | Number of affected lymph nodes predicts outcome in extremity rhabdomyosarcoma |
| Creators Name: | Margotte, Luna, Henssen, Anton, Thorwarth, Anne, Eggert, Angelika and Scheer, Monika |
| Abstract: | BACKGROUND: Rhabdomyosarcoma (RMS) of the extremity have poor outcomes due to high potential for lymphatic and haematogenic spread. METHODS: Data were selected from the SEER17 registry 2000-2020 for nonpleomorphic extremity rhabdomyosarcoma (all ages and stages). RESULTS: 473 cases were identified, 181 at upper and 292 at lower extremity. Median age was 14years. Histology was alveolar in 250. The medium tumor size was 7cm. 144 tumors were localized, 131 regional and 178 distant (20 unknown). Median follow-up for 229 survivors was 8.17years. 5-year-DSS and OS was 49.7%±4.9(95% CI) and 46.3%±4.9, respectively. A total of 169 patients underwent pathological examination of regional lymph nodes. In 51, one node was examined, in 24 two and in 63 ≥3 nodes were examined. Overall, 85 patients had pathologically positive nodes: 36 had one positive regional lymph node, 12 had two and 15 had ≥3. When adjusted for age, histology, size and stage, involvement of ≥3 lymph nodes was independently associated with worse survival. This observation was also applicable to the Cox regression analysis that exclusively considered those 275 cases of localized/regional stage. CONCLUSION: The number of regional lymph nodes affected correlate with survival, suggesting the extent of lymph node involvement as a new and crucial predictive factor. Further analysis of the extent of regional lymph node involvement is advisable. This includes identifying the most effective methods for detecting affected nodes and establishing how many nodes need to be examined to obtain representative results. |
| Keywords: | Soft Tissue Sarcoma, Rhabdomyosarcoma, Extremity, Lymph Node, Prognostic Factors, Risk Stratification, Cross-Age Study, Population-Based, Site of Metastases |
| Source: | European Journal of Surgical Oncology |
| ISSN: | 0748-7983 |
| Publisher: | Elsevier |
| Page Range: | 110535 |
| Number of Pages: | 1 |
| Date: | 25 October 2025 |
| Official Publication: | https://doi.org/10.1016/j.ejso.2025.110535 |
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