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| Item Type: | Article |
|---|---|
| Title: | Association of a lifestyle risk index with visceral and subcutaneous adipose tissue in the German National Cohort (NAKO) |
| Creators: |
Maskarinec, Gertraud  ORCID: https://orcid.org/0000-0002-8129-958X, Klapp, Rebecca ORCID: https://orcid.org/0009-0006-6057-1050, Nöthlings, Ute, Schulze, Matthias B., Bamberg, Fabian, Machann, Jürgen, Schlesinger, Sabrina, Leitzmann, Michael, Sedlmeier, Anja, Bohmann, Patricia, Rospleszcz, Susanne ORCID: https://orcid.org/0000-0002-4788-2341, Nattenmüller, Johanna, Haueise, Tobias, Steindorf, Karen, Niendorf, Thoralf ORCID: https://orcid.org/0000-0001-7584-6527, Schlett, Christopher L., Greiser, Karin Halina, Panreck, Leo, Linseisen, Jakob, Conzen, Christina-Alexandra, Gastell, Sylvia, Schikowski, Tamara, Völzke, Henry, Bülow, Robin, Peters, Annette, Niedermayer, Fiona, Kaaks, Rudolf, Becher, Heiko, Karch, André, Berger, Klaus, Keil, Thomas, Krist, Lilian, Hoffmeister, Michael, Mons, Ute ORCID: https://orcid.org/0000-0003-1764-6783, Schmidt, Boerge, Stang, Andreas, Mikolajczyk, Rafael, Kluttig, Alexander, Lieb, Wolfgang, Övermöhle, Cara, Hebestreit, Antje, Günther, Kathrin, Harth, Volker, Obi, Nadia, Castell, Stefanie, Kettlitz, Robyn, Nimptsch, Katharina ORCID: https://orcid.org/0000-0001-7877-205X and Pischon, Tobias ORCID: https://orcid.org/0000-0003-1568-767X
|
| Abstract: | OBJECTIVE: This cross-sectional study examined a Lifestyle Risk Factor Index (LSRI) in relation to adiposity measures including visceral adipose tissue (VAT) in the German National Cohort (NAKO). METHODS: Based on self-reports at baseline among 30,920 of > 205,000 NAKO eligible participants with magnetic resonance imaging (MRI) scans, one point each for not smoking, adhering to ≥ 3/7 diet recommendations, consuming ≤ 1 (women)/≤ 2 (men) alcoholic drinks/day, and ≥ 150 min/week physical activity was assigned. VAT volume, obtained from whole-body MRI at 3T, was analyzed by deep learning-based image segmentation. General linear models estimated adjusted geometric mean adiposity measures by LSRI and stratified analyses by sex and BMI. RESULTS: Of 18,508 participants aged 48.2 ± 12.2 years, the respective proportions for 0/1, 2, 3, and 4 LSRI points were 7%, 24%, 51%, and 18%. Participants with LSRI scores of 4 versus 0/1 had lower adjusted geometric mean volumes of VAT (2.3; 95% CI 2.2, 2.3 vs. 3.0; 95% CI 2.9, 3.1 L). These differences were slightly attenuated after adding BMI. This association was weaker for individuals with obesity than normal/overweight. CONCLUSION: A combination of lifestyle factors appears to be associated with lower VAT volume, but an elevated BMI may have a greater influence on VAT accumulation than lifestyle behaviors alone. |
| Keywords: | Body Fat Distribution, Cohort Study, Lifestyle Behaviors, Obesity |
| Source: | Obesity |
| ISSN: | 1930-7381 |
| Publisher: | Wiley / The Obesity Society |
| Volume: | 34 |
| Number: | 1 |
| Page Range: | 246-257 |
| Date: | January 2026 |
| Official Publication: | https://doi.org/10.1002/oby.70071 |
| PubMed: | View item in PubMed |
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