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| Item Type: | Article |
|---|---|
| Title: | Cell-based immune anticipation of the omicron variant in SARS-CoV-2 triple-vaccinated cancer patients |
| Creators Name: | Mairhofer, Mario, Kausche, Lea, Kaltenbrunner, Sabine, Pammer, Maria, Ghanem, Riad, Stegemann, Maike and Schmitt, Clemens A. |
| Abstract: | SARS-CoV-2 infections affect healthcare systems worldwide. Patients with cancer, a particularly vulnerable group, and oncology care takers were offered early access to mRNA-based vaccinations. We report the dynamics of humoral and cellular immune response parameters of 74 patients with cancer and 12 control participants after two basal vaccinations and a booster six months later. Upon booster vaccination, 78% of patients with tumor under active therapy (versus 50.8% prior to the boost) exhibited humoral and cellular spike protein responses, as compared to 100% and 73.3%, respectively, in those without active therapy. Conducted prior to the emergence of the Omicron variant of concern, we found Wuhan-Hu-1 spike-encoding mRNA vaccination to evoke T cell responses against peptides outside and within the Omicron-mutated region of the spike protein. The vast majority of patients with cancer achieved significant antibody titers upon repeated vaccinations. Accordingly, patients with tumor appeared well-protected, indicated by asymptomatic or mild breakthrough infections during the Omicron wave. |
| Keywords: | Health Sciences, Medicine, Medical Specialty, Immunology, Oncology |
| Source: | iScience |
| ISSN: | 2589-0042 |
| Publisher: | Cell Press |
| Volume: | 28 |
| Number: | 11 |
| Page Range: | 113727 |
| Number of Pages: | 1 |
| Date: | 21 November 2025 |
| Official Publication: | https://doi.org/10.1016/j.isci.2025.113727 |
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