Prime Editing Corrects RBM20-Mediated Dilated Cardiomyopathy in Human Cardiomyocytes

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Item Type:	Dataset
Title:	Prime Editing Corrects RBM20-Mediated Dilated Cardiomyopathy in Human Cardiomyocytes
Abstract:	The goal of the study is to establish Prime Editing (PE) in differentiated, non-dividing human cardiomyocytes to precisely repair patient-derived DCM mutations to wildtype. We focus on three pathogenic DCM-causing mutations within the human LMNA and RBM20 genes. Our results support further pre-clinical development of PE-based therapies, particularly for RBM20-P633L-associated DCM.
Source:	BioProject
Publisher:	National Library of Medicine
Date:	2 July 2025
External Fulltext:	View full text on external repository or document server
Related to:	URL URL Type https://edoc.mdc-berlin.de/25772/ Publication https://trace.ncbi.nlm.nih.gov/Traces/?view=study&acc=SRP596918 External Dataset https://edoc.mdc-berlin.de/25774/ Dataset https://edoc.mdc-berlin.de/25775/ Dataset https://edoc.mdc-berlin.de/25776/ Dataset https://edoc.mdc-berlin.de/25778/ Dataset https://edoc.mdc-berlin.de/25779/ Dataset https://edoc.mdc-berlin.de/25780/ Dataset https://edoc.mdc-berlin.de/25781/ Dataset https://edoc.mdc-berlin.de/25782/ Dataset https://edoc.mdc-berlin.de/25783/ Dataset https://edoc.mdc-berlin.de/25784/ Dataset https://edoc.mdc-berlin.de/25785/ Dataset https://edoc.mdc-berlin.de/25786/ Dataset https://edoc.mdc-berlin.de/25787/ Dataset https://edoc.mdc-berlin.de/25788/ Dataset https://edoc.mdc-berlin.de/25789/ Dataset

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