Immunomodulatory activity of isolated phenanthrene and dihydrophenanthrene derivatives (coelotrinins A-L) from Coelogyne trinervis

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Item Type:	Article
Title:	Immunomodulatory activity of isolated phenanthrene and dihydrophenanthrene derivatives (coelotrinins A-L) from Coelogyne trinervis
Creators Name:	Pengdee, Chattarika, Dehlinger, Adeline, Thant, May Thazin, Naini, Al Arofatus, Fajriah, Sofa, Punpreuk, Yanyong, Mekboonsonglarp, Wanwimon, Kongkatitham, Virunh, Jungsuttiwong, Siriporn, Chaotham, Chatchai, Böttcher, Chotima and Sritularak, Boonchoo
Abstract:	Twelve previously undescribed compounds, named coelotrinins A-L (1-12), comprising eight dihydrophenanthrene derivatives (1, 4-5, and 7-11), two phenanthrene derivatives (2-3), and two phenanthrene-dihydrophenanthrene derivatives (6 and 12), along with 21 known compounds (13-33), were isolated from the pseudobulbs of Coelogyne trinervis. The structures were elucidated via spectroscopic data analysis, and their configurations were determined by optical rotation values and by comparing experimental and calculated electronic circular dichroism curves. Among these compounds, four compounds 1, 16, 23, and 24 showed immunomodulatory effects by inhibiting LPS-induced TNF-α production in THP-1 monocytes. Only coelotrinin A (1) exhibited an immunomodulatory effect with suppression on human peripheral blood mononuclear cells isolated from patients with multiple sclerosis.
Keywords:	Coelogyne Trinervis, Orchidaceae, Phenanthrene, Dihydrophenanthrene, PBMCs, Multiple Sclerosis, Immunomodulatory Effects
Source:	Phytochemistry
ISSN:	0031-9422
Publisher:	Elsevier
Page Range:	114676
Date:	14 September 2025
Official Publication:	https://doi.org/10.1016/j.phytochem.2025.114676
PubMed:	View item in PubMed

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