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| Item Type: | Article |
|---|---|
| Title: | Central serous chorioretinopathy occurs in high frequency in myelin oligodendrocyte glycoprotein antibody disease, seropositive and seronegative neuromyelitis optica spectrum disorders compared to multiple sclerosis and healthy controls |
| Creators Name: | Knaack, Bianca, Rolfs, Janine, Zimmermann, Hanna G., Patel, Vivek R., Reeß, Lukas G., Bereuter, Charlotte, Schroeter, Jan, Siebert, Nadja, Ruprecht, Klemens, Bellmann-Strobl, Judith, Paul, Friedemann, Brandt, Alexander U. and Oertel, Frederike C. |
| Abstract: | BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) are autoimmune inflammatory disorders of the central nervous system. Central serous chorioretinopathy (CSCR) is characterized by a serous retinal detachment with leakage of fluid through the retinal pigment epithelium accumulating under the retina. This study investigated a potential association between CSCR and these neuroinflammatory disorders. METHODS: We included people with aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive NMOSD (N = 39), multiple sclerosis (MS, N = 39), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD, N = 13), seronegative NMOSD (SN-NMOSD, N = 9), and healthy controls (HC, N = 30). Using optical coherence tomography (OCT), we assessed CSCR frequency and the thickness of the peripapillary retinal nerve fiber layer (pRNFL). RESULTS: There was a higher CSCR frequency (21.3%) throughout all investigated subgroups (AQP4-IgG seropositive NMOSD, MOGAD, and SN-NMOSD) than in the HC group (p = 0.048), with a significant association between CSCR and arterial hypertension frequency but not with these diagnoses, retinal neuroaxonal loss, or history of optic neuritis. CONCLUSION: The high frequency of CSCR suggests a potential benefit of routine monitoring of CSCR in patients with NMOSD and MOGAD using the OCT technology, a reliable method to detect and monitor CSCR in patients with neuroinflammatory disorders. Further research is necessary to establish the underlying pathophysiology and potential effects on vision. |
| Source: | Journal of Neuro-Ophthalmology |
| ISSN: | 1070-8022 |
| Publisher: | Lippincott Williams & Wilkins |
| Page Range: | 1-6 |
| Date: | 13 August 2025 |
| Official Publication: | https://doi.org/10.1097/wno.0000000000002355 |
| PubMed: | View item in PubMed |
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