Estimation of multicomponent flow in the kidney with multi-b-value spectral diffusion

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Item Type:	Article
Title:	Estimation of multicomponent flow in the kidney with multi-b-value spectral diffusion
Creators Name:	Liu, Mira M, Gladytz, Thomas, Dyke, Jonathan, Bolger, Ian, Jasse, Jonas, Calle, Sergio, Crews, Tanner, Seshan, Surya, Salvatore, Steven, Stillman, Isaac, Muthukumar, Thangamani, Taouli, Bachir, Farouk, Samira, Bane, Octavia and Lewis, Sara
Abstract:	PURPOSE: Examine the theory and potential clinical application of estimated intravoxel “flow” of separated perfusion, tubular flow, and tissue diffusion from multi-b-value DWI in kidney allografts. METHODS: Multi-b-value DWI (nine b-values; 0–800 s/mm(2)) from a kidneycortex is simulated with anisotropic and non-Gaussian (i.e., anomalous) vas-cular, tubular, and tissue components and analyzed with a Bayesian biexpo-nential, least-squares triexponential, and spectral diffusion MRI. Comparisonand application of biexponential, triexponential, and spectral diffusion flowproxies as the product of signal fraction f and diffusion coefficient D, fD foreach component, is demonstrated in a two-center study of 54 kidney allograftspatients (21 females/33 males, 48.8 ± 10.5 years, NCT05058170) and comparedto fibrosis (Banff 2017 interstitial fibrosis and tubular atrophy score 0–6 fromclinical biopsies of the renal cortex), impaired kidney function (Chronic Kid-ney Disease Epidemiology Collaboration 2021 estimated glomerular filtrationrate<45 mL/min/1.73 m(2)), and proteinuria (mg/24 h). RESULTS: Spectral diffusion fD demonstrated strong correlation to input fD ofthe simulated anisotropic and anomalous components. It agreed with boththree-component diffusion (y = 1.10x − 0.1, R(2) = 0.74) and two-component dif-fusion (y = 1.01 + 0.2, R(2) = 0.88). fD showed similar or improved agreementand correlation to input than the individual parameters f and D, and spectraldiffusion showed similar or improved agreement than corresponding bi- andtriexponential models. In kidney allografts, fD from spectral diffusion showedthat allografts with higher fibrosis score had higher fD(tissue) (one-way analysis ofvariance F-statistic = 3.86, p = 0.02) and that allografts with impaired functionhad reduced fD(tubule) (Mann–Whitney U-test = −2.14, p = 0.04). Across diagnostic groups of function and fibrosis, fD(vasc) negatively correlated with proteinuria(y = −348x + 1144, p = 0.035 R(2) = 0.82). CONCLUSIONS: Spectral diffusion MRI with multi-Gaussian fD as a flow proxyseparated different anomalous and anisotropic diffusion components of perfu-sion, tubular flow, and tissue diffusion and may hold clinical value in diffusionMRI of kidney pathophysiology.
Keywords:	Diffusion, Kidney Disease, MRI
Source:	Magnetic Resonance in Medicine
ISSN:	0740-3194
Publisher:	Wiley / International Society for Magnetic Resonance in Medicine
Page Range:	1-17
Date:	28 July 2025
Official Publication:	https://doi.org/10.1002/mrm.30644
PubMed:	View item in PubMed

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