Guilty by insolubility - does a protein's detergent insolubility reflect a caveolar location?

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Item Type:	Comment
Title:	Guilty by insolubility - does a protein's detergent insolubility reflect a caveolar location?
Creators Name:	Kurzchalia, T.V., Hartmann, E. and Dupree, P.
Abstract:	Several recent papers have described a simple approach to isolate caveolae and proteins involved in apical sorting in epithelial cells that is based on their detergent insolubility. These publications have excited such diverse fields of cell biology as intracellular protein transport, signal transduction and, in particular, research into caveolae. In this article, Kurzchalia, Hartmann and Dupree argue that a more critical evaluation of this detergent insolubility is needed before a subcellular location or function can be ascribed to a protein.
Source:	Trends in Cell Biology
ISSN:	0962-8924
Publisher:	Elsevier Science
Volume:	5
Number:	5
Page Range:	187-189
Number of Pages:	3
Date:	May 1995
Official Publication:	https://doi.org/10.1016/0962-8924(95)80002-X

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