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Cardiac regeneration: unraveling the complex network of intercellular crosstalk

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Item Type:Review
Title:Cardiac regeneration: unraveling the complex network of intercellular crosstalk
Creators Name:Wu, B., Constanty, F. and Beisaw, A.
Abstract:The heart is composed of multiple cell types, including cardiomyocytes, endothelial/endocardial cells, fibroblasts, resident immune cells and epicardium and crosstalk between these cell types is crucial for proper cardiac function and homeostasis. In response to cardiac injury or disease, cell-cell interactions and intercellular crosstalk contribute to remodeling to compensate reduced heart function. In some vertebrates, the heart can regenerate following cardiac injury. While cardiomyocytes play a crucial role in this process, additional cell types are necessary to create a pro-regenerative microenvironment in the injured heart. Here, we review recent literature regarding the importance of cellular crosstalk in promoting cardiac regeneration and provide insight into emerging technologies to investigate cell-cell interactions in vivo. Lastly, we explore recent studies highlighting the importance of inter-organ communication in response to injury and promotion of cardiac regeneration. Importantly, understanding how intercellular and inter-organ crosstalk promote cardiac regeneration is essential for the development of therapeutic strategies to stimulate regeneration in the human heart.
Keywords:Cell-Cell Interaction, Intercellular Crosstalk, Cardiac Regeneration, Inter-Organ Communication, Animals, Zebrafish, Mice
Source:Seminars in Cell & Developmental Biology
ISSN:1084-9521
Publisher:Elsevier / Academic Press
Volume:171
Page Range:103619
Date:July 2025
Official Publication:https://doi.org/10.1016/j.semcdb.2025.103619
PubMed:View item in PubMed

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