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| Item Type: | Review |
|---|---|
| Title: | Cardiac regeneration: unraveling the complex network of intercellular crosstalk |
| Creators Name: | Wu, B., Constanty, F. and Beisaw, A. |
| Abstract: | The heart is composed of multiple cell types, including cardiomyocytes, endothelial/endocardial cells, fibroblasts, resident immune cells and epicardium and crosstalk between these cell types is crucial for proper cardiac function and homeostasis. In response to cardiac injury or disease, cell-cell interactions and intercellular crosstalk contribute to remodeling to compensate reduced heart function. In some vertebrates, the heart can regenerate following cardiac injury. While cardiomyocytes play a crucial role in this process, additional cell types are necessary to create a pro-regenerative microenvironment in the injured heart. Here, we review recent literature regarding the importance of cellular crosstalk in promoting cardiac regeneration and provide insight into emerging technologies to investigate cell-cell interactions in vivo. Lastly, we explore recent studies highlighting the importance of inter-organ communication in response to injury and promotion of cardiac regeneration. Importantly, understanding how intercellular and inter-organ crosstalk promote cardiac regeneration is essential for the development of therapeutic strategies to stimulate regeneration in the human heart. |
| Keywords: | Cell-Cell Interaction, Intercellular Crosstalk, Cardiac Regeneration, Inter-Organ Communication, Animals |
| Source: | Seminars in Cell & Developmental Biology |
| ISSN: | 1084-9521 |
| Publisher: | Elsevier / Academic Press |
| Volume: | 171 |
| Page Range: | 103619 |
| Date: | July 2025 |
| Official Publication: | https://doi.org/10.1016/j.semcdb.2025.103619 |
| PubMed: | View item in PubMed |
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