From womb to world: the interplay between maternal immune activation, neuroglia, and neurodevelopment

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Item Type:	Book Section
Title:	From womb to world: the interplay between maternal immune activation, neuroglia, and neurodevelopment
Creators Name:	Mattei, D., Guneykaya, D., Ugursu, B. and Buonfiglioli, A.
Abstract:	This chapter introduces and discusses maternal immune activation (MIA) as a contributing factor in increasing the risk of neurodevelopmental disorders, particularly in relation to its interactions with neuroglia. Here we first provide an overview of the neuroglia—astroglia, oligodendroglia, microglia, and radial glial cells—and their important role during early brain development and in adulthood. We then present and discuss MIA, followed by a critical overview of inflammatory molecules and temporal stages associated to maternal inflammation during pregnancy. We provide an overview of animal and human models used to mimic and study MIA. Furthermore, we review the possible interaction between MIA and neuroglia, focusing on the current advances in both modeling and therapeutics. Additionally, we discuss and provide preliminary and interesting insights into the most recent pandemic, COVID-19, and how the infection may be associated to MIA and increased risk for neurodevelopmental disorders. Finally, we provide a critical overview of challenges and future opportunities to study how MIA may contribute to higher risk of developing neurodevelopmental disorders.
Keywords:	Animals, Brain, COVID-19, Neurodevelopmental Disorders, Neuroglia, Pregnancy, Prenatal Exposure Delayed Effects
Source:	Handbook of Clinical Neurology
Series Name:	Handbook of Clinical Neurology
Title of Book:	Handbook of Clinical Neurology
ISSN:	0072-9752
ISBN:	978-0-443-19102-2
Publisher:	Elsevier
Volume:	210: Neuroglia in Neurologic and Psychiatric Disorders, Part II
Page Range:	269-285
Number of Pages:	385
Date:	25 March 2025
Official Publication:	https://doi.org/10.1016/b978-0-443-19102-2.00028-4
PubMed:	View item in PubMed

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