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| Item Type: | Article |
|---|---|
| Title: | Third-trimester NT-proBNP for pre-eclampsia risk prediction: a comparison with sFlt-1/PlGF in a population-based cohort |
| Creators Name: | Bacmeister, L., Buellesbach, A., Glintborg, D., Jorgensen, J.S., Luef, B.M., Birukov, A., Heidenreich, A., Lindner, D., Keller, T., Kraeker, K., Zeller, T., Dechend, R., Andersen, M.S. and Westermann, D. |
| Abstract: | BACKGROUND: The association between lower first-trimester N-terminal pro B-type natriuretic peptide (NT-proBNP) levels and increased pre-eclampsia risk remains poorly understood, contrasting with the elevated NT-proBNP levels observed at the time of pre-eclampsia diagnosis. OBJECTIVES: The aim of this study was to assess the utility of third-trimester NT-proBNP for assessing pre-eclampsia risk before onset. METHODS: NT-proBNP and the soluble Fms-like tyrosine kinase 1 to placental growth factor ratio (sFlt-1/PlGF) were measured in 1,476 pregnant individuals from the Odense Child Cohort at a median gestational age of 29 weeks (Q1-Q3: 28.4-29.4). Pre-eclampsia cases were categorized by timing: 11 individuals (0.7%) developed pre-eclampsia within 4 weeks, while 110 (7.5%) developed pre-eclampsia more than 4 weeks after sampling. RESULTS: Higher NT-proBNP levels were significantly associated with increased risk of pre-eclampsia within 4 weeks but reduced risk beyond 4 weeks. After adjusting for age, body mass index, nulliparity, systolic blood pressure, and the sFlt-1/PlGF ratio, the adjusted OR was 2.18 (95% CI: 0.88-5.42, P = 0.09) for onset within 4 weeks and 0.72 (95% CI: 0.55-0.93, P = 0.012) for onset beyond 4 weeks. However, combining NT-proBNP with the sFlt-1/PlGF ratio did not improve the predictive accuracy for short- or long-term pre-eclampsia risk compared to the sFlt-1/PlGF ratio alone. CONCLUSIONS: Unselected NT-proBNP screening in the early third trimester has limited clinical value for predicting short- or long-term pre-eclampsia risk when compared to angiogenic biomarkers. |
| Keywords: | Cardio-Obstetrics, Hypertension, Natriruretic Peptides, Pre-Eclampsia, Risk Prediction |
| Source: | JACC: Advances |
| ISSN: | 2772-963X |
| Publisher: | Elsevier / American College of Cardiology |
| Volume: | 4 |
| Number: | 4 |
| Page Range: | 101671 |
| Date: | April 2025 |
| Official Publication: | https://doi.org/10.1016/j.jacadv.2025.101671 |
| PubMed: | View item in PubMed |
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