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| Item Type: | Article |
|---|---|
| Title: | Smoking status and vascular risk factors as predictors of disability in AQP4-NMOSD and MOGAD |
| Creators Name: | Chan, F., Berhanu, D., Samadzadeh, S., Francis, A., Asgari, N., Paul, F., Leite, M.I., Geraldes, R. and Palace, J. |
| Abstract: | BACKGROUND: Smoking and vascular risk factors (VRFs) are reported to have adverse effects in multiple sclerosis but data are limited in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD). This study aimed to measure their impact on disability. METHODS: Smoking status was defined as never, past or current smokers and VRF comprised of ⩾1: hypertension, dyslipidemia, high body mass index or diabetes. Logistic regression models were fitted to predict their influence on recovery from attack and attack. RESULTS: A total of 442 patients were included. Current MOGAD smokers had a higher risk of disability from onset attack and first ON attack than never smokers (odds ratio (OR) 2.9, 95% confidence interval (CI) 1.3-6.9; OR 3.3, 95% CI 1.4-7.8). VRF in MOGAD was not predictive of disability. Current AQP4-NMOSD smokers and VRFs had a higher risk of residual disability from onset attacks (OR 7.5, 95% CI 2.1-27.7; OR 1.9, 95% CI 1.0-3.4). VRF was associated with higher risk of visual disability (OR 2.6, 95% CI 1.08-6.46) while smoking status was not. CONCLUSIONS: Current smoking status detrimentally influenced onset attack recovery in AQP4-NMOSD and MOGAD patients, including visual recovery in MOGAD. Non-smoking VRFs influenced clinical and visual outcomes in AQP4-NMOSD. |
| Keywords: | Smoking, Comorbidities, Vascular Risk Factors, Aquaporin-4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein Antibody Disease, Disability |
| Source: | Multiple Sclerosis Journal |
| ISSN: | 1352-4585 |
| Publisher: | Sage Publications |
| Page Range: | 13524585251325069 |
| Date: | 15 March 2025 |
| Official Publication: | https://doi.org/10.1177/13524585251325069 |
| PubMed: | View item in PubMed |
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