Highlights from the plenary session: cellular and molecular mechanisms of disease (I)

Tools

Item Type:	Article
Title:	Highlights from the plenary session: cellular and molecular mechanisms of disease (I)
Creators Name:	Zimmermann, J., Schreiber, A., Heeringa, P. and Te Velde-Keyzer, C.A.
Abstract:	In this plenary session of the Vasculitis Workshop 2024, pioneering translational research on autoimmune vasculitis, particularly ANCA-associated vasculitis (AAV), was presented, highlighting advancements in our understanding of disease mechanisms and promising therapeutic prospects. Advances in elucidating molecular pathways, such as IL-17 and IFN-I, pave the way for specific treatments. Preclinical studies have revealed the gut microbiome's role in the pathogenesis of MPO-AAV and demonstrate the therapeutic potential of dietary interventions. Furthermore, research into the protective role of Tregs has shed light on potential new targets for therapeutic interventions. Innovative approaches, such as CAR-T cell therapy and Deoxy Mab DX-1/DX-3, show significant promise in mitigating AAV pathology. These advancements underscore the transformative potential of translational research. By enhancing our understanding of disease mechanisms, these findings pave the way for the development of personalized and effective therapies, ultimately enhancing patient outcomes.
Keywords:	AAV, Vasculitis, MPO, GCA, Translational Research, CAR-T Cells, Microbiome, Novel Treatment
Source:	Rheumatology
ISSN:	1462-0324
Publisher:	Oxford University Press
Volume:	64
Number:	Supplement_1
Page Range:	i85-i87
Date:	March 2025
Official Publication:	https://doi.org/10.1093/rheumatology/keae411
PubMed:	View item in PubMed

Repository Staff Only: item control page