Helicobacter pylori, microbiota and gastric cancer - principles of microorganism-driven carcinogenesis

Tools

Item Type:	Review
Title:	Helicobacter pylori, microbiota and gastric cancer - principles of microorganism-driven carcinogenesis
Creators Name:	Wizenty, J. and Sigal, M.
Abstract:	The demonstration that Helicobacter pylori is a pathogenic bacterium with marked carcinogenic potential has paved the way for new preventive approaches for gastric cancer. Although decades of research have uncovered complex interactions of H. pylori with epithelial cells, current insights have refined our view on H. pylori-associated carcinogenesis. Specifically, the cell-type-specific effects on gastric stem and progenitor cells deep in gastric glands provide a new view on the ability of the bacteria to colonize long-term, manipulate host responses and promote gastric pathology. Furthermore, new, large-scale epidemiological data have shed light on factors that determine why only a subset of carriers progress to gastric cancer. Currently, technological advances have brought yet another revelation: H. pylori is far from the only microorganism able to colonize the stomach. Instead, the stomach is colonized by a diverse gastric microbiota, and there is emerging evidence for the occurrence and pathological effect of dysbiosis resulting from an aberrant interplay between H. pylori and the gastric mucosa. With the weight of this evidence mounting, here we consider how the lessons learned from H. pylori research inform and synergize with this emerging field to bring a more comprehensive understanding of the role of microbes in gastric carcinogenesis.
Source:	Nature Reviews Gastroenterology & Hepatology
ISSN:	1759-5045
Publisher:	Springer Nature
Date:	26 February 2025
Official Publication:	https://doi.org/10.1038/s41575-025-01042-2
PubMed:	View item in PubMed

Repository Staff Only: item control page