Diminazene aceturate (DIZE) ameliorates hypertension and induces anxiolytic- and antidepressant-like effects in TGR(Mren2)27

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Item Type:	Article
Title:	Diminazene aceturate (DIZE) ameliorates hypertension and induces anxiolytic- and antidepressant-like effects in TGR(Mren2)27
Creators Name:	Costa, Laura Amado, Mourão, Flávio A.G., Alenina, Natalia, Bader, Michael, Campagnole-Santos, Maria José and Kangussu, Lucas M.
Abstract:	INTRODUCTION: Diminazene aceturate (DIZE) was described as an angiotensin-converting enzyme 2 (ACE2) activator. ACE2/Angiotensin-(1-7)/Mas receptor axis presents protective actions on cardiovascular diseases and plays an important modulatory role in the neurobiology of mood and anxiety disorders. OBJECTIVES: To evaluate the effects of chronic intracerebroventricular (ICV) treatment with DIZE on blood pressure, anxiety- and depression-like behaviors in hypertensive transgenic (mRen2)27 rats (TGR). METHODS: Male TGR and Sprague-Dawley rats (10-12 weeks old) were subjected to chronic ICV infusion of DIZE (1.0 μg/h for 7 days). Blood pressure and heart rate were measured by tail plethysmography and anxiety- and depression-like behaviors were evaluated through elevated plus maze, marble burying and forced swim tests, respectively. RESULTS: Treatment with DIZE induced a significant reduction in mean arterial pressure in both TGR and SD rats. A decrease in heart rate was only observed in the hypertensive animals. Additionally, treatment with DIZE attenuated the anxiety- and depression-like behaviors that were observed in TGR. CONCLUSION: DIZE has central anti-hypertensive, anxiolytic, and anti-depressive effects.
Keywords:	Diminazene Aceturate, TGR(mRen2)27, Hypertension, Anxiety, Depression, Animals, Rats
Source:	Protein and Peptide Letters
ISSN:	0929-8665
Publisher:	Bentham
Volume:	32
Number:	4
Page Range:	243-252
Date:	2025
Official Publication:	https://doi.org/10.2174/0109298665357730250213050214
PubMed:	View item in PubMed

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