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| Item Type: | Article |
|---|---|
| Title: | The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination |
| Creators Name: | Maatz, H., Lindberg, E.L., Adami, E., López-Anguita, N., Perdomo-Sabogal, A., Cócera Ortega, L., Patone, G., Reichart, D., Myronova, A., Schmidt, S., Elsanhoury, A., Klein, O., Kühl, U., Wyler, E., Landthaler, M., Yousefian, S., Haas, S., Kurth, F., Teichmann, S.A., Oudit, G.Y., Milting, H., Noseda, M., Seidman, J.G., Seidman, C.E., Heidecker, B., Sander, L.E., Sawitzki, B., Klingel, K., Doeblin, P., Kelle, S., Van Linthout, S., Hubner, N. and Tschöpe, C. |
| Abstract: | Myocarditis, characterized by inflammatory cell infiltration, can have multiple etiologies, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or, rarely, mRNA-based coronavirus disease 2019 (COVID-19) vaccination. The underlying cellular and molecular mechanisms remain poorly understood. In this study, we performed single-nucleus RNA sequencing on left ventricular endomyocardial biopsies from patients with myocarditis unrelated to COVID-19 (Non-COVID-19), after SARS-CoV-2 infection (Post-COVID-19) and after COVID-19 vaccination (Post-Vaccination). We identified distinct cytokine expression patterns, with interferon-γ playing a key role in Post-COVID-19, and upregulated IL16 and IL18 expression serving as a hallmark of Post-Vaccination myocarditis. Although myeloid responses were similar across all groups, the Post-Vaccination group showed a higher proportion of CD4(+) T cells, and the Post-COVID-19 group exhibited an expansion of cytotoxic CD8(+) T and natural killer cells. Endothelial cells showed gene expression changes indicative of vascular barrier dysfunction in the Post-COVID-19 group and ongoing angiogenesis across all groups. These findings highlight shared and distinct mechanisms driving myocarditis in patients with and without a history of SARS-CoV-2 infection or vaccination. |
| Source: | Nature Cardiovascular Research |
| ISSN: | 2731-0590 |
| Publisher: | Springer Nature |
| Date: | 24 February 2025 |
| Official Publication: | https://doi.org/10.1038/s44161-025-00612-6 |
| PubMed: | View item in PubMed |
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