Quality assurance in metabolomics and metabolic profiling

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Item Type:	Article
Title:	Quality assurance in metabolomics and metabolic profiling
Creators Name:	Kirwan, J.A., Bruning, U. and Mosley, J.D.
Abstract:	Metabolic profiling (untargeted metabolomics) aims for a global unbiased analysis of metabolites in a cell or biological system. It remains a highly useful research tool used across various analytical platforms. Incremental improvements across multiple steps in the analytical process may have large consequences for the end quality of the data. Thus, this chapter concentrates on which aspects of quality assurance can be implemented by a lab in the (pre-)analytical stages of the analysis to improve the overall end quality of their data. The scope of this chapter is limited to liquid-chromatography-mass spectrometry (LC-MS)-based profiling, which is one of the most widely utilized platforms, although the general principles are applicable to all metabolomics experiments.
Keywords:	Quality Assurance, Quality Control, Quality Management, Validation, Robust Method, Metabolomics, Untargeted, Mass Spectrometry, NMR, Data Quality
Source:	Methods in Molecular Biology
Series Name:	Methods in Molecular Biology
Title of Book:	Metabolic profiling: methods and protocols
ISSN:	1064-3745
ISBN:	978-1-0716-4333-4
Publisher:	Springer / Humana Press
Volume:	2891
Page Range:	15-51
Number of Pages:	37
Date:	16 January 2025
Official Publication:	https://doi.org/10.1007/978-1-0716-4334-1_2
PubMed:	View item in PubMed

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