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| Item Type: | Article |
|---|---|
| Title: | The clinical effect of probiotic-containing product on health indicators among a population of Central Asia |
| Creators Name: | Kushugulova, A.R., Forslund, S.K., Kozhakhmetov, S.S., Kairov, U.E., Molkenov, A.B., Sergazy, S.D., Saduakhassova, S.A., Urazbayeva, G.S., Beysembayeva, S.C., Karabaeva, R.Z., Bakenova, R.A., Nurgozhin, T.S., Benberin, V.V., Zhumadilov, Z.S. and Bork, P. |
| Abstract: | INTRODUCTION: The main goal is to test the efficacy of a synbiotic product which consists of the selected probiotic strains (Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium bifidum), inulin, pectin, and fish collagen in adults diagnosed with metabolic syndrome. MATERIALS AND METHODS: This double-blind placebo-controlled trial was conducted among 180 participants aged 25 to 75 years. Subjects with and without metabolic syndrome were randomly assigned to receive synbiotic or placebo daily for three months. 134 of 180 participants completed the study. RESULTS: Compared with the placebo group, the synbiotic group had significantly decreased total cholesterol (TC) from 5.16±0.95 to 4.86±0.86 mmol/L, due to lowering the levels of LDL and triglyceride (p <0.0005). The present findings suggest positive influence of the tested synbiotic on controlling excess weight and in treating some metabolic disorders in adults. CONCLUSION: We conclude that the presented synbiotic formulation here has potential within efforts to reduce the risk and progression of the metabolic syndrome. This trial suggests beneficial effects of a synbiotic supplement for controlling excess weight, as well as the progression of some metabolic disorders, as determined from circulating levels of risk factor biomarkers among adults. |
| Keywords: | Synbiotic, Metabolic Syndrome, Lipid Profile |
| Source: | Science & Healthcare |
| ISSN: | 2410-4280 |
| Publisher: | Semey Medical University |
| Volume: | 22 |
| Number: | 2 |
| Page Range: | 49-60 |
| Date: | 30 April 2020 |
| Official Publication: | https://doi.org/10.34689/SH.2020.22.2.005 |
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